India is an emporium of medicinal plants. Indian systems of medicine as well as folkloric systems are utilizing medicinal plant wealth from very ancient times for combating a wide array of human ailments. There exists a history of facing several pandemics including Small pox, Tuberculosis, Spanish Flu, Malaria etc. using traditional herbal medicines. National Medicinal Plant Board had suggested selected twenty medicinal plants including Amla, Aswagandha, Basil, Giloe, Cinnamon, Clove etc. as a prophylaxis or support therapy for curing COVID-19 related ailments. In addition, in silo, in vitro and pre-clinical evidences exhibiting the anti-COVID-19 activity of these medicinal plants revealed the scope for development of plant derived anti-COVID drugs.